Supt20^{Gt(RRK304)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Supt20^{Gt(RRK304)Byg}
• Name: SPT20 SAGA complex component; gene trap RRK304, BayGenomics
• MGI ID: MGI:3699954
• Synonyms: p38IP^RRK
• Gene: Supt20 Location: Chr3:54600228-54636187 bp, + strand Genetic Position: Chr3, 25.59 cM, cytoband D
• Alliance: Supt20^{Gt(RRK304)Byg} page

Mutation origin

• Mutant Cell Line: RRK304
• Germline Transmission: Earliest citation of germline transmission: J:106348
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• Mutation details: A gene trap insertion in the seventh intron was predicted to fuse the first 133 amino acids to a betagal and neo cassette. The absence of normal transcript demonstrated that this allele is likely a null or a severe hypomorph. (J:106348)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRK304	CC894042 ; (MGI Seq Detail)	5' RACE	Chr3:54608904-54610591 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  9 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Supt20 Mutation: 41 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:106348 Zohn IE, et al., p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell. 2006 Jun 2;125(5):957-69
• All: 4 reference(s)