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Furintm1Jwmc
Targeted Allele Detail
Summary
Symbol: Furintm1Jwmc
Name: furin, paired basic amino acid cleaving enzyme; targeted mutation 1, John W M Creemers
MGI ID: MGI:3700008
Synonyms: furfl, Furflox, Furinflox
Gene: Furin  Location: Chr7:80038942-80055188 bp, - strand  Genetic Position: Chr7, 45.65 cM, cytoband D1-E2
Alliance: Furintm1Jwmc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118515
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to flank exon 2 with loxP sites. A floxed neo included in the vector was subsequently removed via transient cre expression. (J:118515)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Furin Mutation:  48 strains or lines available
References
Original:  J:118515 Roebroek AJ, et al., Limited redundancy of the proprotein convertase furin in mouse liver. J Biol Chem. 2004 Dec 17;279(51):53442-50
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory