Furin^tm1Jwmc
Targeted Allele Detail

Summary

• Symbol: Furin^tm1Jwmc
• Name: furin, paired basic amino acid cleaving enzyme; targeted mutation 1, John W M Creemers
• MGI ID: MGI:3700008
• Synonyms: fur^fl, Fur^flox, Furin^flox
• Gene: Furin Location: Chr7:80038942-80055188 bp, - strand Genetic Position: Chr7, 45.65 cM, cytoband D1-E2
• Alliance: Furin^tm1Jwmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118515
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to flank exon 2 with loxP sites. A floxed neo included in the vector was subsequently removed via transient cre expression. (J:118515)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Furin Mutation: 48 strains or lines available

References

• Original: J:118515 Roebroek AJ, et al., Limited redundancy of the proprotein convertase furin in mouse liver. J Biol Chem. 2004 Dec 17;279(51):53442-50
• All: 19 reference(s)