Ptger1^tm1Crjk
Targeted Allele Detail

Summary

• Symbol: Ptger1^tm1Crjk
• Name: prostaglandin E receptor 1 (subtype EP1); targeted mutation 1, Chris R J Kennedy
• MGI ID: MGI:3700011
• Synonyms: EP1^-
• Gene: Ptger1 Location: Chr8:84393307-84399382 bp, + strand Genetic Position: Chr8, 40.22 cM
• Alliance: Ptger1^tm1Crjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118519
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: A mutation was introduced resulting in a stop codon in the coding region at amino acid position 242, thereby halting translation at the beginning of the third cytoplasmic loop. (J:118519)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptger1 Mutation: 22 strains or lines available

References

• Original: J:118519 Kennedy CR, et al., Urine concentrating defect in prostaglandin EP1-deficient mice. Am J Physiol Renal Physiol. 2007 Feb;292(2):F868-75
• All: 5 reference(s)