Ptpn13^tm1Gru
Targeted Allele Detail

Summary

• Symbol: Ptpn13^tm1Gru
• Name: protein tyrosine phosphatase, non-receptor type 13; targeted mutation 1, Michael J Grusby
• MGI ID: MGI:3700029
• Gene: Ptpn13 Location: Chr5:103573058-103746169 bp, + strand Genetic Position: Chr5, 50.43 cM, cytoband E-F
• Alliance: Ptpn13^tm1Gru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118426
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted to disrupt the exon encoding amino acids 452-526. Northern blot confirmed absence of transcript in mutants. (J:118426)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn13 Mutation: 96 strains or lines available

References

• Original: J:118426 Nakahira M, et al., Regulation of Signal Transducer and Activator of Transcription Signaling by the Tyrosine Phosphatase PTP-BL. Immunity. 2007 Feb;26(2):163-76
• All: 1 reference(s)