Ing1^{Gt(OST206270)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Ing1^{Gt(OST206270)Lex}
• Name: inhibitor of growth family, member 1; gene trap OST206270, Lexicon Genetics
• MGI ID: MGI:3700145
• Synonyms: p37^Ing1
• Gene: Ing1 Location: Chr8:11605762-11613251 bp, + strand Genetic Position: Chr8, 5.73 cM
• Alliance: Ing1^{Gt(OST206270)Lex} page

Mutation origin

• Mutant Cell Line: OST206270
• Germline Transmission: Earliest citation of germline transmission: J:118602
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector was inserted into exon 3 of the locus, interrupting the coding of the longer transcript. (J:118602)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST206270	CG573968 ; (MGI Seq Detail)	3' RACE	Chr8:11611415-11611972 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  14 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ing1 Mutation: 25 strains or lines available

References

• Original: J:118602 Coles AH, et al., Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis. Cancer Res. 2007 Mar 1;67(5):2054-61
• All: 3 reference(s)