Fadd^tm1Mpa
Targeted Allele Detail

Summary

• Symbol: Fadd^tm1Mpa
• Name: Fas associated via death domain; targeted mutation 1, Manolis Pasparakis
• MGI ID: MGI:3700154
• Synonyms: Fadd^fl
• Gene: Fadd Location: Chr7:144132060-144136178 bp, - strand Genetic Position: Chr7, 88.85 cM
• Alliance: Fadd^tm1Mpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118336
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette. (J:167475)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fadd Mutation: 18 strains or lines available

References

• Original: J:118336 Luedde T, et al., Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell. 2007 Feb;11(2):119-32
• All: 19 reference(s)