Gli3^tm1Blnw
Targeted Allele Detail

Summary

• Symbol: Gli3^tm1Blnw
• Name: GLI-Kruppel family member GLI3; targeted mutation 1, Baolin Wang
• MGI ID: MGI:3700159
• Synonyms: Gli3^delta68
• Gene: Gli3 Location: Chr13:15638308-15904611 bp, + strand Genetic Position: Chr13, 5.43 cM, cytoband A2
• Alliance: Gli3^tm1Blnw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118340
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A vector was designed to delete 68 residues, resulting in the fusion of residue 675 to 743. A floxed neo included in the vector was subsequently removed from the locus. (J:118340)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli3 Mutation: 81 strains or lines available

References

• Original: J:118340 Wang C, et al., A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype. Dev Dyn. 2007 Mar;236(3):769-76
• All: 2 reference(s)