Chrna4^tm1Jbou
Targeted Allele Detail

Summary

• Symbol: Chrna4^tm1Jbou
• Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1, Jim Boulter
• MGI ID: MGI:3700204
• Synonyms: Chrna4^S252F
• Gene: Chrna4 Location: Chr2:180664104-180685339 bp, - strand Genetic Position: Chr2, 103.54 cM
• Alliance: Chrna4^tm1Jbou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118273
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: The S252F mutation was introduced. A floxed neo was removed from the locus via cre mediated recombination. (J:118273)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Chrna4 Mutation: 44 strains or lines available

References

• Original: J:118273 Klaassen A, et al., Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19152-7
• All: 2 reference(s)