Gpr4^tm1Witt
Targeted Allele Detail

Summary

• Symbol: Gpr4^tm1Witt
• Name: G protein-coupled receptor 4; targeted mutation 1, Owen N Witte
• MGI ID: MGI:3700206
• Synonyms: Gpr4^-
• Gene: Gpr4 Location: Chr7:18946463-18958099 bp, + strand Genetic Position: Chr7, 9.46 cM
• Alliance: Gpr4^tm1Witt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118276
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was replaced by the IRES-GFP and PGK-neo cassette. Absence of transcript was confirmed by RT-PCR. (J:118276)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr4 Mutation: 19 strains or lines available

References

• Original: J:118276 Yang LV, et al., Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Mol Cell Biol. 2007 Feb;27(4):1334-47
• All: 7 reference(s)