Dlg4^tm1Rlh
Targeted Allele Detail

Summary

• Symbol: Dlg4^tm1Rlh
• Name: discs large MAGUK scaffold protein 4; targeted mutation 1, Richard L Huganir
• MGI ID: MGI:3700207
• Synonyms: Dlg4^-
• Gene: Dlg4 Location: Chr11:69908029-69938107 bp, + strand Genetic Position: Chr11, 42.96 cM, cytoband B4
• Alliance: Dlg4^tm1Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118286
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons encoding PDZ 1 and 2 domains were replaced with a neomycin resistance cassette. This results in the production of an out of frame transcript. Western blot confirmed absence of protein in mutant mice. (J:118286)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlg4 Mutation: 46 strains or lines available

References

• Original: J:118286 Beique JC, et al., Synapse-specific regulation of AMPA receptor function by PSD-95. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19535-40
• All: 6 reference(s)