Vcp^tm1.1Dts
Targeted Allele Detail

Summary

• Symbol: Vcp^tm1.1Dts
• Name: valosin containing protein; targeted mutation 1.1, D T Shima
• MGI ID: MGI:3700224
• Synonyms: p97^-
• Gene: Vcp Location: Chr4:42979964-43000507 bp, - strand Genetic Position: Chr4, 22.95 cM
• Alliance: Vcp^tm1.1Dts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118184
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed tk-neo cassette was inserted upstream of exon 1 and a third loxP site was inserted into intron 1. Cre mediated recombination removed the neo cassette and exon 1. (J:118184)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vcp Mutation: 52 strains or lines available

References

• Original: J:118184 Muller JM, et al., Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality. Biochem Biophys Res Commun. 2007 Mar 9;354(2):459-465
• All: 1 reference(s)