Nedd9^tm1Miku
Targeted Allele Detail

Summary

• Symbol: Nedd9^tm1Miku
• Name: neural precursor cell expressed, developmentally down-regulated gene 9; targeted mutation 1, Mineo Kurokawa
• MGI ID: MGI:3700233
• Synonyms: Cas-L^-
• Gene: Nedd9 Location: Chr13:41463392-41640836 bp, - strand Genetic Position: Chr13, 20.43 cM
• Alliance: Nedd9^tm1Miku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116716
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.2 kb region that includes exon 2 was replaced with EGFP and a floxed neo cassette. Western blot analysis of homozygous thymus cell lysates confirmed absence of the full length protein. (J:116716)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nedd9 Mutation: 34 strains or lines available

References

• Original: J:116716 Seo S, et al., Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance. J Immunol. 2005 Sep 15;175(6):3492-501
• All: 15 reference(s)