Trpm4^tm1.1Mfre
Targeted Allele Detail

Summary

• Symbol: Trpm4^tm1.1Mfre
• Name: transient receptor potential cation channel, subfamily M, member 4; targeted mutation 1.1, Marc Freichel
• MGI ID: MGI:3700529
• Synonyms: Trpm4^-
• Gene: Trpm4 Location: Chr7:44952579-44983495 bp, - strand Genetic Position: Chr7, 29.24 cM
• Alliance: Trpm4^tm1.1Mfre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118679
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Cre mediated recombination was used to remove exons 15 and 16 from the locus. (J:118679)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm4 Mutation: 59 strains or lines available

References

• Original: J:118679 Vennekens R, et al., Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4. Nat Immunol. 2007 Mar;8(3):312-320
• All: 17 reference(s)