Eif4ebp1^tm1Pjb
Targeted Allele Detail

Summary

• Symbol: Eif4ebp1^tm1Pjb
• Name: eukaryotic translation initiation factor 4E binding protein 1; targeted mutation 1, Paul J Blackshear
• MGI ID: MGI:3700567
• Synonyms: PHAS-I^-
• Gene: Eif4ebp1 Location: Chr8:27750355-27765684 bp, + strand Genetic Position: Chr8, 15.95 cM, cytoband A4-B1
• Alliance: Eif4ebp1^tm1Pjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44600
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a ne cassette via homologous recombination. Northern blot analysis detected expression of a novel transcript and and western blot analysis confirmed the absence of protein in homozygous MEFs. (J:44600)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif4ebp1 Mutation: 33 strains or lines available

References

• Original: J:44600 Blackshear PJ, et al., Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice. J Biol Chem. 1997 Dec 12;272(50):31510-4
• All: 1 reference(s)