Syne2^tm1Rexu
Targeted Allele Detail

Summary

• Symbol: Syne2^tm1Rexu
• Name: spectrin repeat containing, nuclear envelope 2; targeted mutation 1, Rener Xu
• MGI ID: MGI:3700736
• Synonyms: Syne-2^-
• Gene: Syne2 Location: Chr12:75865092-76157702 bp, + strand Genetic Position: Chr12, 33.11 cM
• Alliance: Syne2^tm1Rexu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118671
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The last two exons were replaced with a neo cassette. RT-PCR confirmed removal of the KASH domain. Immunohistochemistry confirmed loss of localization of the protein to the nuclear envelope in homozygous skeletal muscle cells. (J:118671)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syne2 Mutation: 297 strains or lines available

References

• Original: J:118671 Zhang X, et al., Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. Development. 2007 Mar;134(5):901-8
• All: 4 reference(s)