Tg(TcraY1,TcrbY1)416Tev
Transgene Detail

Summary

• Symbol: Tg(TcraY1,TcrbY1)416Tev
• Name: transgene insertion 416, Satvir S Tevethia
• MGI ID: MGI:3700739
• Synonyms: line 416 TCR-I, Tag-I, TCR-I
• Transgene: Tg(TcraY1,TcrbY1)416Tev Location: unknown
• Alliance: Tg(TcraY1,TcrbY1)416Tev page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1/J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraY1,TcrbY1)416Tev expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Single-cell embryos were coinjected with T-cell receptor alpha and T-cell receptor beta expression vectors containing the rearranged genomic Tcra and Tcrb VJ/V(D)J segments from the cytotoxic T-lymphocyte clone Y-1, which expresses a T cell receptor specific for the H2-D^b-restricted SV40 large tumor antigen epitope I (amino acids 206-215). (J:84288)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic mouse lines were derived from 2 transgene-expressing founder mice and designated lines 416 and 422. The Tg insert of line 416 was backcrossed onto C57BL/6 to create a congenic strain for use in experiments.

References

• Original: J:84288 Staveley-O'Carroll K, et al., In vivo ligation of CD40 enhances priming against the endogenous tumor antigen and promotes CD8+ T cell effector function in SV40 T antigen transgenic mice. J Immunol. 2003 Jul 15;171(2):697-707
• All: 19 reference(s)