Rag2^tm1Libo
Targeted Allele Detail

Summary

• Symbol: Rag2^tm1Libo
• Name: recombination activating gene 2; targeted mutation 1, Lisa Borghesi
• MGI ID: MGI:3700748
• Synonyms: Erag-
• Gene: Rag2 Location: Chr2:101455063-101462874 bp, + strand Genetic Position: Chr2, 53.87 cM
• Alliance: Rag2^tm1Libo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84563
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.3Kb region upstream of Rag2 containing a putative enchancer (Erag) was replaced with a floxed neo cassette subsequently removed via cre mediated recombination. (J:84563)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rag2 Mutation: 119 strains or lines available

References

• Original: J:84563 Hsu LY, et al., A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. Immunity. 2003 Jul;19(1):105-17
• All: 5 reference(s)