Tg(Tcra2D2,Tcrb2D2)1Kuch
Transgene Detail

Summary

• Symbol: Tg(Tcra2D2,Tcrb2D2)1Kuch
• Name: transgene insertion 1, Vijay Kuchroo
• MGI ID: MGI:3700794
• Synonyms: 2D2, 2D2 TCR, MOG TCR, MOG^TCR, TCR^MOG, TCRMOG
• Transgene: Tg(Tcra2D2,Tcrb2D2)1Kuch Location: unknown
• Alliance: Tg(Tcra2D2,Tcrb2D2)1Kuch page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra2D2,Tcrb2D2)1Kuch expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: The Valpha3.2Jalpha18 region of Tcra from the 2D2 T cell clone as well as the Vbeta11DJbeta1,1 region of Tcrb from the same 2D2 clone were inserted into TCR expression cassettes. The linearized plasmids were injected into the pronuclei of fertilized C57BL/6 oocytes. The 2D2 clone was purified from C57BL/6 mice immunized with a peptide from myelin oligodendrocyte glycoprotein (MOG). The amino acid sequence of the CDR3 region from TCR alpha is VYF CALRSY NFG and that from TCR beta is CASS LDCG ANP. (J:83278)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:83278 Bettelli E, et al., Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003 May 5;197(9):1073-81
• All: 306 reference(s)