Mug1^tm2Vln
Targeted Allele Detail

Summary

• Symbol: Mug1^tm2Vln
• Name: murinoglobulin 1; targeted mutation 2, Fred Van Leuven
• MGI ID: MGI:3700943
• Synonyms: MAM^-/MUG-1^-
• Gene: Mug1 Location: Chr6:121815500-121866016 bp, + strand Genetic Position: Chr6, 57.52 cM, cytoband F2
• Alliance: Mug1^tm2Vln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57485
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A targeting construct containing a neomycin resistance gene was inserted into ES cells containing a previously targeted insertion of a hygromycin cassette into exon 17 of the Pzp locus. Deficiency of both proteins was confirmed by Northern blot of mutant liver samples. (J:57485)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mug1 Mutation: 115 strains or lines available

References

• Original: J:57485 Umans L, et al., alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis. Am J Pathol. 1999 Sep;155(3):983-93
• All: 3 reference(s)