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Mug1tm2Vln
Targeted Allele Detail
Summary
Symbol: Mug1tm2Vln
Name: murinoglobulin 1; targeted mutation 2, Fred Van Leuven
MGI ID: MGI:3700943
Synonyms: MAM-/MUG-1-
Gene: Mug1  Location: Chr6:121815500-121866016 bp, + strand  Genetic Position: Chr6, 57.52 cM, cytoband F2
Alliance: Mug1tm2Vln page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57485
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsA targeting construct containing a neomycin resistance gene was inserted into ES cells containing a previously targeted insertion of a hygromycin cassette into exon 17 of the Pzp locus. Deficiency of both proteins was confirmed by Northern blot of mutant liver samples. (J:57485)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mug1 Mutation:  115 strains or lines available
References
Original:  J:57485 Umans L, et al., alpha2-macroglobulin- and murinoglobulin-1- deficient mice. A mouse model for acute pancreatitis. Am J Pathol. 1999 Sep;155(3):983-93
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory