Acaca^tm1.1Jkus
Targeted Allele Detail

Summary

• Symbol: Acaca^tm1.1Jkus
• Name: acetyl-Coenzyme A carboxylase alpha; targeted mutation 1.1, Jun Kusunoki
• MGI ID: MGI:3700955
• Synonyms: Acc1^-, Acc1^deltaex46
• Gene: Acaca Location: Chr11:84020498-84292477 bp, + strand Genetic Position: Chr11, 51.29 cM
• Alliance: Acaca^tm1.1Jkus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118861
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 46 was removed via cre-mediated recombination in the germline. Neither wild-type nor truncated protein was expressed from the locus. (J:118861)

Expression

In Mice Carrying this Mutation:

30 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acaca Mutation: 128 strains or lines available

References

• Original: J:118861 Harada N, et al., Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice. Mol Cell Biol. 2007 Mar;27(5):1881-8
• All: 1 reference(s)