Trp53inp1^tm1Acar
Targeted Allele Detail

Summary

• Symbol: Trp53inp1^tm1Acar
• Name: transformation related protein 53 inducible nuclear protein 1; targeted mutation 1, Alice Carrier
• MGI ID: MGI:3700974
• Synonyms: inp1^-, Trnp53^-
• Gene: Trp53inp1 Location: Chr4:11156441-11174379 bp, + strand Genetic Position: Chr4, 5.03 cM, cytoband A1-A2
• Alliance: Trp53inp1^tm1Acar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118867
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-4 were replaced with a floxed neomycin resistance cassette. The neo was subsequently removed as the targeting vector also contained a cre recombinase gene under the control of the testes-specific angiotensin-converting enzyme gene promoter. RT-PCR confirmed absence of transcript in mutant spleens. (J:118867)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53inp1^tm1Acar

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Trp53inp1 Mutation: 21 strains or lines available

References

• Original: J:118867 Gommeaux J, et al., Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1. Mol Cell Biol. 2007 Mar;27(6):2215-28
• All: 10 reference(s)