Ptpn9^tm1Dny
Targeted Allele Detail

Summary

• Symbol: Ptpn9^tm1Dny
• Name: protein tyrosine phosphatase, non-receptor type 9; targeted mutation 1, Gregory P Downey
• MGI ID: MGI:3700988
• Synonyms: Meg2^-
• Gene: Ptpn9 Location: Chr9:56902252-56970092 bp, + strand Genetic Position: Chr9, 30.7 cM, cytoband C
• Alliance: Ptpn9^tm1Dny page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118880
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 10-12 and part of exon 13 were replaced with a neomycin resistance gene. Northern and Western blot confirmed absence of transcript and protein, respectively. (J:118880)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn9 Mutation: 32 strains or lines available

References

• Original: J:118880 Wang Y, et al., Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med. 2005 Dec 5;202(11):1587-97
• All: 2 reference(s)