Igl^tm2Bgmn
Targeted Allele Detail

Summary

• Symbol: Igl^tm2Bgmn
• Name: immunoglobulin lambda chain complex; targeted mutation 2, Marianne Bruggemann
• MGI ID: MGI:3701068
• Synonyms: C1^-C2^-C3^-, ES2.4
• Gene: Igl Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118712
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Deletion
• Igl^tm2Bgmn involves 5 genes/genome features (Igl, Iglc1, Iglj1 ...) View all
• Mutation details: ES cells containing the C1 to C3 deletion were transfected with a construct designed to insert a floxed neo cassette into C2. This resulted in silencing of C2. (J:118712)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igl Mutation: 3 strains or lines available

References

• Original: J:118712 Zou X, et al., Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain. J Immunol. 2003 Feb 1;170(3):1354-61
• All: 1 reference(s)