Igl^tm2.1Bgmn
Targeted Allele Detail

Summary

• Symbol: Igl^tm2.1Bgmn
• Name: immunoglobulin lambda chain complex; targeted mutation 2.1, Marianne Bruggemann
• MGI ID: MGI:3701069
• Synonyms: 1.3-2.4delta, C1^-C2^-C3^-C4^-, L^-
• Gene: Igl Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118712
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Deletion
• Igl^tm2.1Bgmn involves 12 genes/genome features (Igl, Iglc1, Iglj1 ...) View all
• Mutation details: LoxP insertions and cre-mediated recombination resulted in a 120Kb deletion spanning C1 through C2, and including C2 and C3. (J:118712)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igl Mutation: 3 strains or lines available

References

• Original: J:118712 Zou X, et al., Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain. J Immunol. 2003 Feb 1;170(3):1354-61
• All: 4 reference(s)