Hamp^tm1Svl
Targeted Allele Detail

Summary

• Symbol: Hamp^tm1Svl
• Name: hepcidin antimicrobial peptide; targeted mutation 1, Sophie Vaulont
• MGI ID: MGI:3701082
• Synonyms: Hamp1^-, Hepc1^-
• Gene: Hamp Location: Chr7:30641793-30643454 bp, - strand Genetic Position: Chr7, 19.27 cM
• Alliance: Hamp^tm1Svl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119004
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The first two exons and part of exon 3 was replaced with a PGK-hygromycin cassette. (J:119004)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hamp Mutation: 15 strains or lines available

References

• Original: J:119004 Lesbordes-Brion JC, et al., Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood. 2006 Aug 15;108(4):1402-5
• All: 38 reference(s)