Ptgs2^{tm2(Ptgs1)Fun}
Targeted Allele Detail

Summary

• Symbol: Ptgs2^{tm2(Ptgs1)Fun}
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 2, Colin D Funk
• MGI ID: MGI:3701117
• Synonyms: COX-1 COX-2^flox-neo, ptgs2 Ptgs2^flox-neo
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^{tm2(Ptgs1)Fun} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118171
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Ptgs2^{tm2(Ptgs1)Fun} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Ptgs1

• Mutation details: The cDNA encoding encoding prostaglandin-endoperoxide synthase 1, with an upstream floxed neo cassette replaced most of the coding region of the endogenous locus (exons 1-9). (J:118171)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ptgs2^tm2(Ptgs1)Fun/Ptgs2^tm2(Ptgs1)Fun	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
hematopoietic system	√
abnormal macrophage physiology	√
immune system	√
abnormal macrophage physiology	√
mortality/aging	√
preweaning lethality, incomplete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 73 strains or lines available

References

• Original: J:118171 Yu Y, et al., Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. J Biol Chem. 2007 Jan 12;282(2):1498-506
• All: 1 reference(s)