Ptgs2^{tm2(Ptgs1)Fun}
Targeted Allele Detail

Summary

• Symbol: Ptgs2^{tm2(Ptgs1)Fun}
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 2, Colin D Funk
• MGI ID: MGI:3701117
• Synonyms: COX-1 COX-2^flox-neo, ptgs2 Ptgs2^flox-neo
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^{tm2(Ptgs1)Fun} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118171
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Ptgs2^{tm2(Ptgs1)Fun} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Ptgs1

• Mutation details: The cDNA encoding encoding prostaglandin-endoperoxide synthase 1, with an upstream floxed neo cassette replaced most of the coding region of the endogenous locus (exons 1-9). (J:118171)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 73 strains or lines available

References

• Original: J:118171 Yu Y, et al., Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. J Biol Chem. 2007 Jan 12;282(2):1498-506
• All: 1 reference(s)