H2-M3^tm1Crw
Targeted Allele Detail

Summary

• Symbol: H2-M3^tm1Crw
• Name: histocompatibility 2, M region locus 3; targeted mutation 1, Chung-Ru Wang
• MGI ID: MGI:3701255
• Synonyms: M3^-
• Gene: H2-M3 Location: Chr17:37581111-37585375 bp, + strand Genetic Position: Chr17, 19.16 cM
• Alliance: H2-M3^tm1Crw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118960
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance gene replaced exons 4-6 by homologous recombination. (J:118960)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2-M3 Mutation: 16 strains or lines available

References

• Original: J:118960 Xu H, et al., Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense. J Exp Med. 2006 Feb 20;203(2):449-59
• All: 10 reference(s)