Ptges3^{Gt(RST271)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Ptges3^{Gt(RST271)Byg}
• Name: prostaglandin E synthase 3; gene trap RST271, BayGenomics
• MGI ID: MGI:3701300
• Synonyms: line B, p23^-
• Gene: Ptges3 Location: Chr10:127894851-127913123 bp, + strand Genetic Position: Chr10, 76.39 cM
• Alliance: Ptges3^{Gt(RST271)Byg} page

Mutation origin

• Mutant Cell Line: RST271
• Germline Transmission: Earliest citation of germline transmission: J:117591
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0TMpfs Vector Type: secretory trap
• Mutation details: A gene trap vector containing a Betageo with a splice acceptor and a polyA signal integrated into intron 1. (J:117591)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RST271	CC178633 ; (MGI Seq Detail)	5' RACE	multiple
  * GRCm39; (strand of gene trap mutagenesis)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ptges3 Mutation: 43 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:117591 Grad I, et al., The Hsp90 cochaperone p23 is essential for perinatal survival. Mol Cell Biol. 2006 Dec;26(23):8976-83
• All: 4 reference(s)