Mgrn1^Gt(XC712)Byg
Gene trapped Allele Detail

Summary

• Symbol: Mgrn1^Gt(XC712)Byg
• Name: mahogunin, ring finger 1; gene trap XC712, BayGenomics
• MGI ID: MGI:3701336
• Synonyms: Mgrn1^{Gt(pGT1Lxf)XC712Wcs}, Mgrn1^XC712
• Gene: Mgrn1 Location: Chr16:4704113-4756160 bp, + strand Genetic Position: Chr16, 2.48 cM, cytoband A1
• Alliance: Mgrn1^Gt(XC712)Byg page

Mutation origin

• Mutant Cell Line: XC712
• Germline Transmission: Earliest citation of germline transmission: J:116645
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The gene trap vector inserted into intron 17 resulting in an alternate splice form. RT-PCR analysis confirmed very low levels of expression of isoforms I and III in the brain. Northern blot analysis did not detect expression of any normal length transcripts. (J:119125)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XC712	CC178051 ; (MGI Seq Detail)	5' RACE	Chr16:4745679-4750156 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  37 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:

18 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mgrn1 Mutation: 55 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:119125 Bagher P, et al., Characterization of Mahogunin Ring Finger-1 expression in mice. Pigment Cell Res. 2006 Dec;19(6):635-43
• All: 3 reference(s)