Grin2b^tm1Tya
Targeted Allele Detail

Summary

• Symbol: Grin2b^tm1Tya
• Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1, Tadashi Yamamoto
• MGI ID: MGI:3701351
• Synonyms: NR2B Y1472F-KI, Y1472F-KI, YF
• Gene: Grin2b Location: Chr6:135690231-136150509 bp, - strand Genetic Position: Chr6, 66.38 cM
• Alliance: Grin2b^tm1Tya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119025
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert the Y1472F mutation into the locus. A floxed neo included in the vector was subsequently removed via transient cre expression. (J:119025)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2b Mutation: 99 strains or lines available

References

• Original: J:119025 Nakazawa T, et al., NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J. 2006 Jun 21;25(12):2867-77
• All: 7 reference(s)