Sox10^tm3(Sox8)Weg
Targeted Allele Detail

Summary

• Symbol: Sox10^tm3(Sox8)Weg
• Name: SRY (sex determining region Y)-box 10; targeted mutation 3, Michael Wegner
• MGI ID: MGI:3701358
• Synonyms: Sox10^Sox8ki
• Gene: Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Sox10^tm3(Sox8)Weg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119015
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The Sox8 open reading frame along with an IRES-EGFP and a floxed neo cassette were inserted into exon 3, replacing the entire open reading frame of Sox10. The neo cassette was removed via in vivo Cre mediated recombination. (J:119015)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox10 Mutation: 33 strains or lines available

References

• Original: J:119015 Kellerer S, et al., Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Development. 2006 Aug;133(15):2875-86
• All: 2 reference(s)