Tg(Ins2-Cd274)2Mdos
Transgene Detail

Summary

• Symbol: Tg(Ins2-Cd274)2Mdos
• Name: transgene insertion 2, H Michael Dosch
• MGI ID: MGI:3701452
• Synonyms: RIP-B7H1, RIP-PDL1L
• Transgene: Tg(Ins2-Cd274)2Mdos Location: unknown
• Alliance: Tg(Ins2-Cd274)2Mdos page

Transgene origin

• Strain of Origin: NOD/ShiLt

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins2-Cd274)2Mdos expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD274 (29126)

  Cd274

  (MGI:1926446)

• Tg(Ins2-Cd274)2Mdos expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Ins2 (24506)

  Ins2	(MGI:96573)

• Mutation details: This transgene contains cDNA encoding human CD274 (B7H1) fused to the rat insulin 2 promoter. Transgenic mice express CD274 in pancreatic beta cells. (J:118934)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:118934 Tang L, et al., Non-obese diabetic mice overexpressing CD274 in pancreatic beta cells have an accelerated diabetes phenotype. MGI Direct Data Submission. 2007
• All: 1 reference(s)