Gapdh^M6Neu
Chemically induced Allele Detail

Summary

• Symbol: Gapdh^M6Neu
• Name: glyceraldehyde-3-phosphate dehydrogenase; mutation 6, Neuherberg
• MGI ID: MGI:3701515
• Synonyms: GAPDH2644
• Gene: Gapdh Location: Chr6:125138812-125143450 bp, - strand Genetic Position: Chr6, 59.32 cM, cytoband C
• Alliance: Gapdh^M6Neu page

Mutation origin

• Strain of Origin: (101 x C3H)F1 X T-stock

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Single point mutation
• Mutation details: The isopropyl methanesulfonate- (iPMS-) induced mutation is a G-to-A transition predicted to replace valine (GTC) with isoleucine (ATC) at codon 240 (V240I) in exon 4. (J:126359)
• Inheritance: Dominant

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Gapdh^M6Neu/Gapdh^M6Neu	C3.Cg-Gapdh^M6Neu
ht2	Gapdh^M6Neu/Gapdh^+	C3.Cg-Gapdh^M6Neu

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms
cardiovascular system	N
cardiovascular system phenotype	N
growth/size/body	N
growth/size/body region phenotype	N
hematopoietic system	√
hematopoietic system phenotype	N
abnormal hematocrit	√
decreased hemoglobin content	√
homeostasis/metabolism		√
decreased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity		√
liver/biliary system	N
liver/biliary system phenotype	N
mortality/aging	√	√
preweaning lethality, complete penetrance	√
preweaning lethality, incomplete penetrance		√
renal/urinary system	N
renal/urinary system phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gapdh Mutation: 41 strains or lines available

References

• Original: J:126359 Pretsch W, et al., Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus. Mamm Genome. 2007 Oct;18(10):686-92
• All: 1 reference(s)