Tg(Emx1-cre)3Ito
Transgene Detail

Summary

• Symbol: Tg(Emx1-cre)3Ito
• Name: transgene insertion 3, Shigeyoshi Itohara
• MGI ID: MGI:3701619
• Synonyms: Tg3
• Transgene: Tg(Emx1-cre)3Ito Location: unknown
• Alliance: Tg(Emx1-cre)3Ito page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Emx1-cre)3Ito expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Emx1 (MGI:95387)

• Mutation details: An Emx1 positive PAC clone frome the RPCI-21 PAC mouse genomic library (PAC-Emx1#1) was modified by the insertion of an NLS-Cre-poly(A) cassette into the NotI site by homologous recombination in bacteria. Two independent recombination events were identified. This transgenic line was generated from the PAC-Cre-B fragment and has 7-9 copies of the transgene. (J:88421)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Emx1 (mouse) Summary of all recombinase alleles driven by Emx1. Comparative matrix view of recombinase activities Alliance mouse Emx1 gene page

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Embryonic expression is first seen in the dorsal telencephalon at E10. Adult expression of this transgene is seen in the olfactory bulb, neocortex, piriform cortex, hippocampus and amygdala of the brain. Activity is primarily in excitatory neurons and astrocytes. Little or no activity is seen in inhibitory neurons. Expression is also seen in the thymus, stomach, testes, and some regions of the skin at 7-8 days of age.

References

• Original: J:88421 Iwasato T, et al., Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis. 2004 Mar;38(3):130-8
• All: 7 reference(s)