Unc79^Lwt
Chemically induced Allele Detail

Summary

• Symbol: Unc79^Lwt
• Name: unc-79 homolog; lightweight
• MGI ID: MGI:3701691
• Synonyms: Unc79^Lwt, Unc79^Mlca3
• Gene: Unc79 Location: Chr12:102915118-103150324 bp, + strand Genetic Position: Chr12, 52.68 cM
• Alliance: Unc79^Lwt page

Mutation origin

• Strain of Origin: DBA/2J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The dominant behavioral phenotype of one of the independent loci, Lightweight (Lwt), results from a nonsense mutation in the mouse homolog of the C. elegans unc-79 gene. The mutation results in a G-T transversion at amino acid position 1292 leading to the conversion of a glutamic acid residue to a premature stop codon in exon 27. Immunoblot analysis indicates an absence of the expected band at 290 kDa in mutant versus wildtype homogenates. (J:118059)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc79 Mutation: 126 strains or lines available

References

• Original: J:118059 Speca DJ, et al., A genetic screen for behavioral mutations that perturb dopaminergic homeostasis in mice. Genes Brain Behav. 2006 Feb;5(1):19-28
• All: 2 reference(s)