Tg(APOE-Cyp7a1)1Road
Transgene Detail

Summary

• Symbol: Tg(APOE-Cyp7a1)1Road
• Name: transgene insertion 1, Roger A Davis
• MGI ID: MGI:3701768
• Synonyms: Tg(APOE-CYP7A1)1Rjd
• Transgene: Tg(APOE-Cyp7a1)1Road Location: unknown
• Alliance: Tg(APOE-Cyp7a1)1Road page

Transgene origin

• Strain of Origin: C57BL/6 x 129X1/SvJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE-Cyp7a1)1Road expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Cyp7a1 (25428)

  Cyp7a1

  (MGI:106091)

• Mutation details: This transgene expresses rat Cyp7a1 via the human apoE (liver-specific) enhancer element, also called the hepatic control region (HCR). Expression is seen in the in the liver, but not the kidney, heart, lung, and intestine. (J:70134)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:70134 Miyake JH, et al., Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase. J Biol Chem. 2001 Jun 29;276(26):23304-11
• All: 8 reference(s)