Lamtor2^tm1.2Lah
Targeted Allele Detail

Summary

• Symbol: Lamtor2^tm1.2Lah
• Name: late endosomal/lysosomal adaptor, MAPK and MTOR activator 2; targeted mutation 1, Lukas A Huber
• MGI ID: MGI:3701832
• Synonyms: p14^-
• Gene: Lamtor2 Location: Chr3:88457126-88460258 bp, - strand Genetic Position: Chr3, 38.87 cM
• Alliance: Lamtor2^tm1.2Lah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119075
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 to 4 were deleted by cre-recombination of the region. An IRES-GFP cassette was also inserted to function as a reporter only active following the deletion. Targeted mutation was confirmed by western blot that nulls lacked protein product. (J:119075)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamtor2 Mutation: 15 strains or lines available

References

• Original: J:119075 Teis D, et al., p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J Cell Biol. 2006 Dec 18;175(6):861-8
• All: 1 reference(s)