Apobec2^tm1Msn
Targeted Allele Detail

Summary

• Symbol: Apobec2^tm1Msn
• Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2; targeted mutation 1, Michael S Neuberger
• MGI ID: MGI:3701835
• Gene: Apobec2 Location: Chr17:48726259-48739756 bp, - strand Genetic Position: Chr17, 24.02 cM
• Alliance: Apobec2^tm1Msn page

Myopathy in 8-10-month-old Apobec2^tm1Msn/Apobec2^tm1Msn mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119326
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 2 causing a null allele. A northern blot confirmed the ablation of expression and a western blot of heart and skeletal muscle contained no recognized protein (rabbit anti-APOBEC2 antiserum). (J:119326)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apobec2 Mutation: 17 strains or lines available

References

• Original: J:119326 Mikl MC, et al., Mice deficient in APOBEC2 and APOBEC3. Mol Cell Biol. 2005 Aug;25(16):7270-7
• All: 3 reference(s)