Apobec3^tm1Msn
Targeted Allele Detail

Summary

• Symbol: Apobec3^tm1Msn
• Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3; targeted mutation 1, Michael S Neuberger
• MGI ID: MGI:3701836
• Gene: Apobec3 Location: Chr15:79775860-79800107 bp, + strand Genetic Position: Chr15, 37.85 cM, cytoband E2
• Alliance: Apobec3^tm1Msn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119326
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neo cassette was inserted into exon 3 resulting in a null allele. Targeted mutation was confirmed by northern and western blot that showed no RNA or protein expression, respectively, in spleen tissue. (J:119326)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apobec3 Mutation: 127 strains or lines available

References

• Original: J:119326 Mikl MC, et al., Mice deficient in APOBEC2 and APOBEC3. Mol Cell Biol. 2005 Aug;25(16):7270-7
• All: 5 reference(s)