Smad9^tm2.1Rob
Targeted Allele Detail

Summary

• Symbol: Smad9^tm2.1Rob
• Name: SMAD family member 9; targeted mutation 2.1, Elizabeth J Robertson
• MGI ID: MGI:3701870
• Synonyms: Smad8^-, Smad8 null
• Gene: Smad9 Location: Chr3:54663003-54708678 bp, + strand Genetic Position: Chr3, 25.62 cM, cytoband D
• Alliance: Smad9^tm2.1Rob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119296
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed Hygro cassette was inserted into intron 1 and a loxP site in intron 3. Cre-mediated recombination resulted in the excision of loxP-flanked sequences, resulting in a null allele that lacked exons 2 and 3. (J:119296)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad9 Mutation: 32 strains or lines available

References

• Original: J:119296 Arnold SJ, et al., Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev Biol. 2006 Aug 1;296(1):104-18
• All: 1 reference(s)