Kmt2atm1.1(Sh3gl1)Lcc
Targeted Allele Detail
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Symbol: |
Kmt2atm1.1(Sh3gl1)Lcc |
Name: |
lysine (K)-specific methyltransferase 2A; targeted mutation 1.1, Li Chong Chan |
MGI ID: |
MGI:3701943 |
Synonyms: |
MllEenINV |
Gene: |
Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
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Alliance: |
Kmt2atm1.1(Sh3gl1)Lcc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:205605
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Parent Cell Line: |
Other (see notes) (ES Cell)
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Strain of Origin: |
129S/SvEv
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence, No functional change) |
Mutations: |
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Insertion, Intragenic deletion
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Kmt2atm1.1(Sh3gl1)Lcc expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Sh3gl1 (MGI:700010) |
fusion protein created after cre-mediated recombination |
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Mutation details: A cassette containing a splice acceptor, the open reading frame of Sh3gl1, an IRES-EGFP and an FRT-flanked neomycin resistance cassette was flanked by inward facing loxP sites and inserted in opposite orientation between exon 8 and 9. Flp-mediated recombination removed the selection cassette. Cre-mediated inversion is required to achieve expression of the fusion at exon 8. The fusion products mimick a fusion found in human patients with leukemia.
(J:205605)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kmt2a Mutation: |
135 strains or lines available
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Original: |
J:205605 Ng RK, et al., Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model. J Pathol. 2014 Jan;232(1):65-74 |
All: |
3 reference(s) |
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