Sox1^tm2Vep
Targeted Allele Detail

Summary

• Symbol: Sox1^tm2Vep
• Name: SRY (sex determining region Y)-box 1; targeted mutation 2, Vasso Episkopou
• MGI ID: MGI:3701963
• Synonyms: Sox1^betageo
• Gene: Sox1 Location: Chr8:12445519-12449555 bp, + strand Genetic Position: Chr8, 5.73 cM, cytoband A1-A2
• Alliance: Sox1^tm2Vep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99610
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A betageo fusion protein was inserted in frame into the ORF. The targeted locus produced a fusion protein consisting of the first 50 amino acids from the endogenous protein, excluding the HMG box, followed by ten amino acids encoded by a synthetic linker sequence and the betageo sequence. Wild-type protein was not detected in mutants. (J:99610)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox1 Mutation: 13 strains or lines available

References

• Original: J:99610 Ekonomou A, et al., Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLoS Biol. 2005 Jun;3(6):e186
• All: 4 reference(s)