Sox2^tm1.1Vep
Targeted Allele Detail

Summary

• Symbol: Sox2^tm1.1Vep
• Name: SRY (sex determining region Y)-box 2; targeted mutation 1.1, Vasso Episkopou
• MGI ID: MGI:3701965
• Synonyms: Sox2^betageo, Sox2^betageo2
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^tm1.1Vep page

Sox2^tm1.2Vlcg/Sox2^tm1.2Vlcg and Sox2^tm1.1Vep/Sox2^tm1.2Vlcg embryos form disorganized extraembryonic tissues, but fail to form the epiblast, phenocopying Sox2^tm1.1Vep/Sox2^tm1.1Vep embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99610
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The floxed Sox1 sequence was removed via transient cre mediated recombination, leaving betageo in the locus. (J:99610)

Expression

In Mice Carrying this Mutation:	30 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:99610 Ekonomou A, et al., Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1. PLoS Biol. 2005 Jun;3(6):e186
• All: 4 reference(s)