Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Thomas Ludwig
• MGI ID: MGI:3701992
• Synonyms: ERCre, Gt(ROSA)26Sor-CreER, Gt(ROSA)26Sor^{tm1(cre/ESR1)Thl}, ROSA26Cre-ERT2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104582
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gt(ROSA)26Sor (MGI:104735)

• Mutation details: DNA sequence encoding a fusion protein comprised of cre recombinase and a mutated ligand binding domain of Esr1 (ERT2) was inserted at the endogenous locus via homologous recombination. Activation of cre recombinase activity is dependent on the administration of 4-OH-tamoxifen. (J:104582)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gt(ROSA)26Sor (mouse) Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Alliance mouse Gt(ROSA)26Sor gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 994 strains or lines available

References

• Original: J:104582 de Luca C, et al., Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest. 2005 Dec;115(12):3484-93
• All: 121 reference(s)