Trp53^tm5Tyj
Targeted Allele Detail

Summary

• Symbol: Trp53^tm5Tyj
• Name: transformation related protein 53; targeted mutation 5, Tyler Jacks
• MGI ID: MGI:3702077
• Synonyms: p53^f, p53-LSL, p53^LSL, p53^LSL-WT, Trp53^LSL
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm5Tyj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118233
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• A lox-STOP-lox cassette is inserted into intron 1, disrupting expression of the gene. (J:118233)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm5Tyj

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:118233 Ventura A, et al., Restoration of p53 function leads to tumour regression in vivo. Nature. 2007 Feb 8;445(7128):661-5
• All: 20 reference(s)