Hus1^tm2Rsw
Targeted Allele Detail

Summary

• Symbol: Hus1^tm2Rsw
• Name: HUS1 checkpoint clamp component; targeted mutation 2, Robert S Weiss
• MGI ID: MGI:3702082
• Synonyms: Hus1^neo
• Gene: Hus1 Location: Chr11:8943137-8961191 bp, - strand Genetic Position: Chr11, 5.74 cM
• Alliance: Hus1^tm2Rsw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:99339
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: This allele is the parent allele for Hus1^tm1Rsw, and contains a neomycin resistance cassette flanked with FRT sites and exons 2 and 3 flanked by loxP sites. It was demonstrated to be a hypomorph. (J:99339)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hus1 Mutation: 20 strains or lines available

References

• Original: J:99339 Levitt PS, et al., Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene. Genomics. 2005 Aug;86(2):212-24
• All: 4 reference(s)