Pdx1^tm4Cvw
Targeted Allele Detail

Summary

• Symbol: Pdx1^tm4Cvw
• Name: pancreatic and duodenal homeobox 1; targeted mutation 4, Christopher VE Wright
• MGI ID: MGI:3702084
• Synonyms: Ipf1^tm3Cvw, Pdx1^flE2, Pdx1^tm4(E2)Cvw
• Gene: Pdx1 Location: Chr5:147206907-147212658 bp, + strand Genetic Position: Chr5, 86.84 cM
• Alliance: Pdx1^tm4Cvw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130389
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites for Cre recombinase were inserted to flank exon 2 of the gene. (J:130389)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdx1 Mutation: 35 strains or lines available

References

• Original: J:130389 Gannon M, et al., pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol. 2008 Feb 15;314(2):406-17
• All: 12 reference(s)