Rangap1^{Gt(U3neo)1B6Rul}
Gene trapped Allele Detail

Summary

• Symbol: Rangap1^{Gt(U3neo)1B6Rul}
• Name: RAN GTPase activating protein 1; gene trap 1B6, H Earl Ruley
• MGI ID: MGI:3702086
• Gene: Rangap1 Location: Chr15:81588449-81614120 bp, - strand Genetic Position: Chr15, 38.21 cM
• Alliance: Rangap1^{Gt(U3neo)1B6Rul} page

Mutation origin

• Mutant Cell Line: 1B6
• Germline Transmission: Earliest citation of germline transmission: J:16895
• Parent Cell Line: D3H (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: U3NeoSV1
• Mutation details: The gene trap vector integrated into an alternatively spliced 48bp exon. In situ hybridization experiments suggest that the gene trap integration abolishes expression of all transcripts of the gene, resulting in a null allele. (J:16895, J:151685)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rangap1 Mutation: 47 strains or lines available

References

• Original: J:16895 DeGregori J, et al., A murine homolog of the yeast RNA1 gene is required for postimplantation development. Genes Dev. 1994 Feb 1;8(3):265-76
• All: 2 reference(s)