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Idd4.3C57L
QTL Variant Detail
Summary
QTL variant: Idd4.3C57L
Name: insulin dependent diabetes susceptibility 4.3; C57L
MGI ID: MGI:3702140
QTL: Idd4.3  Location: unknown  Genetic Position: Chr11, Syntenic
Variant
origin
Strain of Specimen:  C57L
Variant
description
Allele Type:    QTL
Mutation:    Undefined
 
Mutation detailsThis allele confers increased diabetes incidence compared to NOD. This allele also confers increased STAT5 phosphorylation and decreased GM-CSF production in unactivated macrophages compared to NOD. (J:118951)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:118951

Congenic line analysis was used to investigate genetic loci involved in diabetes susceptibility, macrophage STAT5 dysfunction, and GM-CSF production. Diabetes-resistant congenic line NOD.LC11 carries C57L-derived DNA on mouse Chromosome 11 encompassing the Idd4 locus and Stat5a/Stat5b/Stat3 genes on a NOD genetic background. Congenic subline NOD.LC11f carries C57L-derived DNA at Csf2 (29 cM), Idd4a (43 cM), and Idd4b (48 cM) while NOD.LC11b carries C57L-derived DNA only at Csf2. Both lines exclude C57L-derived Stat5a/Stat5b/Stat3 genes. NOD.LC11b exhibits a greater incidence of diabetes (27%) compared to NOD.LC11f (19%) indicating the presence of a diabetes susceptibility locus near Csf. This locus is named Idd4c and also exhibits linkage to decreased GM-CSF production and increased STAT5 phosphorylation in unactivated macrophages.

References
Original:  J:118951 Litherland SA, et al., Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction. J Immunol. 2005 Oct 1;175(7):4561-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory