Idd4.3^C57L
QTL Variant Detail

Summary

• QTL variant: Idd4.3^C57L
• Name: insulin dependent diabetes susceptibility 4.3; C57L
• MGI ID: MGI:3702140
• QTL: Idd4.3 Location: unknown Genetic Position: Chr11, Syntenic

Variant origin

• Strain of Specimen: C57L

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased diabetes incidence compared to NOD. This allele also confers increased STAT5 phosphorylation and decreased GM-CSF production in unactivated macrophages compared to NOD. (J:118951)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:118951

Congenic line analysis was used to investigate genetic loci involved in diabetes susceptibility, macrophage STAT5 dysfunction, and GM-CSF production. Diabetes-resistant congenic line NOD.LC11 carries C57L-derived DNA on mouse Chromosome 11 encompassing the Idd4 locus and Stat5a/Stat5b/Stat3 genes on a NOD genetic background. Congenic subline NOD.LC11f carries C57L-derived DNA at Csf2 (29 cM), Idd4a (43 cM), and Idd4b (48 cM) while NOD.LC11b carries C57L-derived DNA only at Csf2. Both lines exclude C57L-derived Stat5a/Stat5b/Stat3 genes. NOD.LC11b exhibits a greater incidence of diabetes (27%) compared to NOD.LC11f (19%) indicating the presence of a diabetes susceptibility locus near Csf. This locus is named Idd4c and also exhibits linkage to decreased GM-CSF production and increased STAT5 phosphorylation in unactivated macrophages.

References

• Original: J:118951 Litherland SA, et al., Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction. J Immunol. 2005 Oct 1;175(7):4561-5
• All: 1 reference(s)