Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:118951Congenic line analysis was used to investigate genetic loci involved in diabetes susceptibility, macrophage STAT5 dysfunction, and GM-CSF production. Diabetes-resistant congenic line NOD.LC11 carries C57L-derived DNA on mouse Chromosome 11 encompassing the Idd4 locus and Stat5a/Stat5b/Stat3 genes on a NOD genetic background. Congenic subline NOD.LC11f carries C57L-derived DNA at Csf2 (29 cM), Idd4a (43 cM), and Idd4b (48 cM) while NOD.LC11b carries C57L-derived DNA only at Csf2. Both lines exclude C57L-derived Stat5a/Stat5b/Stat3 genes. NOD.LC11b exhibits a greater incidence of diabetes (27%) compared to NOD.LC11f (19%) indicating the presence of a diabetes susceptibility locus near Csf. This locus is named Idd4c and also exhibits linkage to decreased GM-CSF production and increased STAT5 phosphorylation in unactivated macrophages. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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