Igh^tm1.1Hws
Targeted Allele Detail

Summary

• Symbol: Igh^tm1.1Hws
• Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Harry W Schroeder
• MGI ID: MGI:3702187
• Synonyms: DeltaD-DFL
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119391
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Deletion
• Igh^tm1.1Hws involves 1 genes/genome features (Igh) View all
• Mutation details: Transient cre expression in ES cells containing Igh^tm1Hws resulted in the deletion of 12 of the 13 DH gene segments from the locus. (J:119391)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:119391 Schelonka RL, et al., A single DH gene segment creates its own unique CDR-H3 repertoire and is sufficient for B cell development and immune function. J Immunol. 2005 Nov 15;175(10):6624-32
• All: 5 reference(s)